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in patients with congestive heart failure, hepatic cirrhosis, or renal disease treated with unat torsemide at doses higher than those studied in united states antihypertensive trials, hypokalemia was observed with greater frequency, in a dose-related manner.

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there was no fetotoxicity or teratogenicity in rats treated with up to 5 mg kg day of unat torsemide sodium on a mg kg basis, this is 15 times a human dose of 20 mg day; on a mg m 2 basis, the animal dose is 10 times the human dose , or in rabbits, treated with 1.

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Patients who received 10 mg to 20 mg of daily unat torsemide sodium in these studies achieved significantly greater reductions in weight and edema than did patients who received placebo.

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