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Since myambutol-inh isoniazid is known to cross the placental barrier, neonates of isoniazid-treated mothers should be carefully observed for any evidence of adverse effects.

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, diabetes, uremia, alcoholism, malnutrition, hiv-infection , as well as pregnant women and persons with a seizure disorder, may be given pyridoxine vitamin b6 10-50 mg day with isoniazid.

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Available data indicate that the standard treatment isoniazid, rifampicin, ethambutol is not teratogenic.

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