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In several in vitro assays for gene mutation, amantadine hydrochloride did not increase the number of spontaneously observed mutations in four strains of salmonella typhimurium ames test or in a mammalian cell line chinese hamster ovary cells when incubations were performed either with or without a liver metabolic activation extract.

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vulnerable patients with an associated or undiagnosed bipolar disorder may require close monitoring while taking amantadine to avoid a manic switch, likely due to the increase in monoamines in the amygdala and hippocampus.

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